The preRC protein ORCA organizes heterochromatin by assembling histone H3 lysine 9 methyltransferases on chromatin

Heterochromatic domains are enriched with repressive bottoms histone marks, including histone H3 lysine 9 methylation, written by lysine methyltransferases (KMTs).The pre-replication complex protein, origin recognition complex-associated (ORCA/LRWD1), preferentially localizes to heterochromatic regions in post-replicated cells.Its role in heterochr

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